Gastrointestinal Pathology - Case 5 - Part 3
   

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Part 5

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 Histo-pathology showed a malignant gastrointestinal stromal tumor grade II/III. The stomach, spleen, and tail of the pancreas were involved. Distal and proximal margins were negative for neoplastic change. There was no evidence of malignancy in 15 lymph nodes. There was normal gastric mucosa overlying the tumor with chronic inflammation.

H & E of tumor low power
C-Kit stain is positive in the tumor cells.
Gastric mucosa with underlying tumor
Gastric mucosa with underlying tumor
High power views show spindle cells with a high mitotic rate.
High power views show spindle cells with a high mitotic rate.
C-kit stain is positive in the tumor cells.
1. What is the cell of origin of this tumor?