Welcome to the Tantin Laboratory
Our interests lie in the elucidation of mammalian transcription factor function and in understanding transcription factor circuitries. Transcription factors are used to achieve specific gene expression patterns. Because these patterns are critical for successful development and signal response, aberrations in transcription factor function frequently underlie human disorders such as cancer and immune dysfunction. Our laboratory employs biochemical, genetic and genomic approaches to determine transcription factor function in stem cells, in tumorigenesis, during lymphocyte development/function, and to elucidate specific gene regulatory circuits in normal and diseased cells. Our efforts focus on gene regulation both from the perspective of mechanisms of action and biological effects of specific transcription factors, as well as the means of coordinate and reciprocal regulation of specific groups of genes.