Multi-Factor Comparison to Predict Recurrence Rate of Meningioma

Meningiomas are the second most common central nervous system tumor. Surgical resection is the most favorable treatment for these tumors. Despite treatment, the inherent biology and location of meningiomas can give it a greater tendency to reoccur. As a result, a clear understanding of recurrence rate determines not only the type but also the aggressiveness of treatment. Certain factors such as proliferative index have been shown to give an indication of recurrence rate. Current methods to determine recurrence rate are inadequate and leave large windows of error. This study will explore multiple factors that, in conjunction, can more accurately approximate the recurrence rate and consequently help plan a more effective treatment. We have collected data on over 250 patients that were treated for meningiomas. This data includes the tumor samples, MRI images, and patient charts. Molecular marker of hypoxia (CA-IX) / hypoxia-regulated angiogenesis (VEGF, HIF-I, and GLUT-1), proliferation (MIB-1), microvascular density (Factor VIII) and edema (COX II) will be examined on all tumor samples. After testing the samples, the MRI images of each patient will be examined for size, extent of necrosis and peritumoral edema. Finally, tumor recurrence and patient survival will be correlated with these factors.

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