Huntsman Cancer Institute and Deptartment of Orthopaedics

E-mail: david.joyner@hci.utah.edu
Address: 4230, Huntsman Cancer Institute
Phone: 585-3451

Research Title:  Doxorubicin-induced survival in sarcomas: a search for
molecular pathways and potential therapeutic targets.

Research description:  Drug resistance in sarcomas may be regulated by cell-cell communication. We hypothesize (a) sarcoma cells transiently exposed to a toxin can enhance communal survival by communicating with unaffected neighboring cells, (b) this capability is inherent in normal cells, but may be amplified by neoplastic transformation.  Intercellular communication in sarcomas and primary fibroblasts will be evaluated in vitro by transiently exposing a subpopulation of cells to doxorubicin or cis-platinum, then combining primed cells with untreated recipient cells, and subsequently subjecting the cells to a near-lethal dose of doxorubicin. This study initiates our efforts at identifying potential molecular therapeutic targets for use against sarcomas.

Does this research involve human subjects or animals?  no

If yes, what is the protocol number?

10/20/06