| David E. Joyner, Ph.D.
Huntsman Cancer Institute and Deptartment of Orthopaedics E-mail: david.joyner@hci.utah.edu Research Title: Doxorubicin-induced survival in sarcomas: a search for |
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Research description: Drug resistance in sarcomas may be regulated by
cell-cell communication. We hypothesize (a) sarcoma cells transiently
exposed to a toxin can enhance communal survival by communicating with
unaffected neighboring cells, (b) this capability is inherent in normal
cells, but may be amplified by neoplastic transformation. Intercellular
communication in sarcomas and primary fibroblasts will be evaluated in vitro
by transiently exposing a subpopulation of cells to doxorubicin or
cis-platinum, then combining primed cells with untreated recipient cells,
and subsequently subjecting the cells to a near-lethal dose of doxorubicin.
This study initiates our efforts at identifying potential molecular
therapeutic targets for use against sarcomas. 10/20/06 |
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