Pathology

E-mail: david.stillman@utah.edu
Address: 15 N. Medical Drive, Rm 2100
Phone: 581-5429

yFACT in transcriptional regulation.

We are studying the role of yFACT in regulating gene expression in collaboration with Tim Formosa’s laboratory. In addtion to the previously described roles in transcriptional elongation and for replication. We have shown a role for yFACT in regulating transcriptional initiation at the level of stimulating binding of the basal transcription factors TBP and TFIIA to promoters. We also show that the yFACT works in opposition to two chromatin modifying factors, the Chd1 chromodomain protein and the Set2 histone methyl transferase.

1/2008