Dean Tantin, Ph.D.
2006, Assistant Professor, University of Utah School of Medicine, Department of Pathology
Faculty Assistant: Kim Antry, B.S.
Scholarly Emphasis: genetic, biochemical & proteomic analysis of transcription factors in mammalian cells
Our interests lie in the elucidation of mammalian transcription factor function and in understanding transcription factor circuitries. Transcription factors are used to achieve specific gene expression patterns. Because these patterns are critical for successful development and signal response, aberrations in transcription factor function frequently underlie human disorders such as cancer and immune dysfunction. Our laboratory employs biochemical, genetic and genomic approaches to determine transcription factor function in stem cells, in tumorigenesis, during lymphocyte development/function, and to elucidate specific gene regulatory circuits in normal and diseased cells. Our efforts focus on gene regulation both from the perspective of mechanisms of action and biological effects of specific transcription factors, as well as the means of coordinate and reciprocal regulation of specific groups of genes.
- Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. (2013) Dynamic regulatory network controlling TH17 cell differentiation. Nature. 496:461
- Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin D. (2012) Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet. 8:e1003048
- Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother WG. (2011) Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome Res. 21:1055
- Shakya A, Kang J, Chumley J, Williams MA, Tantin D. (2011) Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. J. Biol. Chem. 286:450
- Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. (2009) Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat. Cell Biol. 11:320
- Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D. (2009) A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev. 23:208
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Honors and Awards
- 2008, March of Dimes/Basil O'Connor Starter Scholar Award
- 2004, Postdoctoral Research Fellowship, The Medical Foundation, Charles A. King Trust
- 2000, Postdoctoral Research Fellowship, Irvington Institute for Immunological Research
- 2005, Fellow in Gene Regulation and Molecular Genetics, Massachusetts Institute of Technology, Center for Cancer Research and Department of Biology, Cambridge, MA
- 1997, Ph.D. in Molecular Biology, University of California, Los Angeles, Molecular Biology Institute Interdepartmental Ph.D. Program
- 1992, B.S. in Molecular Biology, University of California, San Diego, Division of Biology, La Jolla, CA