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Frederic Clayton, M.D.
Associate Professor of Pathology
Dr. Frederic Clayton
Titles:
- Autopsy Director
- Pathology Course Master for pathology courses 6010 and 6020 for the 1st and 2nd year Medical Students
- Curriculum Committee
About Frederic Clayton, M.D.
Dr. Clayton directs the autopsy service and the first and second year medical student pathology courses. He has studied various aspects of the enteric changes in HIV infection, specifically the inflammatory changes associated with various stages of HIV infection were described and a novel mechanism for HIV-associated malabsorption / enteropathy, involving the HIV-activated G-protein coupled receptor GPR-15/Bob was discovered. He also described how an HIV-associated intestinal infection, cryptosporidiosis, varies among different patients, and that the distribution of the infection determined the symptoms and prognosis.
He has also developed a staining method for Gb3, a glycosphingolipid that is the receptor for Shiga toxin, which is important for hemolytic uremic syndrome. He has shown the distribution of this receptor, and that, in contrast to earlier reports, Gb3 does not vary appreciably with age. Gb3 expression is increased after exposure to lipopolysaccharide.
Recent work has focused on the immunologic aspects of amniotic fluid embolism syndrome, documenting the role of complement fixation on the embolic material in the pathogenesis of this process, which bears a clinical resemblance to septic shock.A
Selected Publications
- Clayton F, Pysher TJ, Lou R, Kohan DE, Denkers ND, Tesh VL, Taylor FB, Siegler RL:
- Lipopolysaccharide Upregulates Renal Shiga Toxin Receptors in a Primate Model of Hemolytic Uremic Syndrome. American Journal of Nephrology 25:536-540, 2005.
- Clayton F, Kotler DP, Kuwada SK, Morgan T, Stepan C, Kuang J, Le J, Fantini J: Gp120-Induced GPR15/Bob Activation - A Possible Cause of HIV Enteropathy. American Journal of Pathology 159:1933-1939, 2001.
- Clayton F, Tessnow KA, Fang JC, Holden JA, Moore JG: Circadian Variation of Topoisomerase II-Alpha In Human Rectal Crypt Epithelium: Implications for Reduction of Toxicity of Chemotherapy. Modern Pathology 15:1191-1196, 2002.
- Maresca M, Mahfoud R, Garmy N, Kotler DP, Fantini J, Clayton F. The virotoxin model of HIV-1 enteropathy : involvement of GPR15/Bob and galactosyl ceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line. Journal of Biomedical Science 10:156-66, 2003.
- Ergonul Z, Clayton F, Fogo A, Kohan DE: Renal Shiga Toxin -1 Binding and Receptor Expression Do Not Explain the Age-Related Incidence of Post-Diarrheal Hemolytic-Uremic Syndrome. Pediatric Nephrology 18:246-53, 2003.
- Clayton F, Kapetanovic SK, Kotler DP: Enteric Microtubule depolymerization in HIV Infection - a Possible Cause of HIV-Associated Enteropathy. AIDS 15:123-4, 2001.
- Clayton F, Snow G, Reka S, Kotler DP. Selective Depletion of Rectal Lamina Propria Rather than Lymphoid Aggregate CD4 Lymphocytes in HIV Infection. Clinical and Experimental Immunology 107:288-92, 1997.
- Kotler DP, Shimada T, Snow G, Winson G, Chen W, Zhao M, Inada Y, Clayton F. Effect of Combination Antiretroviral Therapy upon Rectal Mucosal HIV RNA Burden and Mononuclear Cell Apoptosis. AIDS 12:597-604, 1998.
- Clayton F, Heller T, and Kotler DP. Variation in the Enteric Distribution of Cryptosporidiosis in AIDS. Am J Clin Pathol 102:420-5, 1994.
- Clayton F, Reka S, Cronin WJ, Torlakovic E, Sigal S, and Kotler DP: Rectal Mucosal Pathology Varies with Human Immunodeficiency Virus Antigen Content and Disease Stage. Gastroenterology 103:919-933, 1992.
- All Publications: Click Here
Honors and Awards
- Phi beta Kappa, 1972, Rice University