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Joseph Holden, M.D., Ph.D.
2002-Present: Professor, Department of Pathology, University of Utah
1994-2002: Associate Professor, Department of Pathology, University of Utah
1987-1994: Assistant Pofessor, Department of Pathology, University of Utah
Scholarly Emphasis:
C-kit and PDGFRA mutations, DNA topoisomerases, Gastrointestinal Stromal Tumors (GIST)
Titles:
- Medical Director, Gene Rearrangement Section, Hematopathology Laboratory, University of Utah Hospital (1987-1994)
About Joseph Holden, M.D., Ph.D.
Dr. Holden’s current research is aimed at detecting the presence or absence of tyrosine kinase activating mutations in human malignancies. This may help guide therapy with new targeted anticancer drugs.
Selected Publications
- Holden JA and Low RL. Potent catenation activity of Hela cell nuclei, J.Biol. Chem., 260:14491-14497, 1985.
- Low RL and Holden JA. Inhibition of Hela cell topoisomerase I by ATP and phosphate. Nucl. Acids Res., 13:6999-7014, 1985.
- Cummings OW, King TC, Holden JA, and Low RL. Purification and characterization of the potent endonuclease in extracts of bovine heart mitochondria. J. Biol. Chem., 262:2005-2015, 1987.
- Holden JA, Rolfson DH, and Wittwer CT. Human DNA topoisomerase II: evaluation of enzyme activity in normal and neoplastic tissues. Biochemistry, 29:2127-2134, 1990.
- Holden JA, Rolfson DH, and Low RL. DNA topoisomerase I from human placenta. Biochimica et Biophysica Acta., 1049:303-310, 1990.
- Holden JA, Dresler SL, and Low RL. Identification of DNA Topoisomerase II Activity in Terminally Differentiated Mammalian Organs and in Non-Growing Cultured Cells. Enzyme, 43:197-206, 1990.
- Hopfenbeck JA, Holden JA, Wittwer CT, and Kjeldsberg CR. Digoxigenin-labeled probes amplified from genomic DNA detect T-cell gene rearrangements. American Journal of Clinical Pathology, 97:638-644, 1992.
- Holden JA, Rolfson DH, and Wittwer CT. The distribution of immunoreactive DNA topoisomerase II protein in human tissues and neoplasms. Oncology Research, 4:157-166, 1992.
- Juenke JM and Holden JA. The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues. Biochimica et Biophysica Acta, 1216:191-196, 1993.
- Holden JA, Snow GW, Perkins SL, Jolles CJ, and Kjeldsberg CR. Immunohistochemical staining for DNA topoisomerase II in frozen and formalin fixed paraffin embedded human tissues. Modern Pathology, 7:829-834, 1994.
- Holden JA, Perkins SL, Snow GW, and Kjeldsberg CR. Immunohistochemical staining for DNA topoisomerase II in non-Hodgkin's lymphomas. Amer. J.
- All Publications: Click Here
Professional Education
- B.S. Rutgers University, 1971
- Ph.D. Duke University, 1975 (Biochemistry)
- M.D. University of Michigan, 1982