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Arthur Brothman, Ph.D.
Professor Pediatrics
Adjunct Professor Human Genetics
Adjunct Professor Pathology
Arthur Brothman, Ph.D.
Titles:
- Medical Director, Cytogenetics & Molecular Cytogenetics, ARUP Laboratories
About Arthur Brothman, Ph.D.
Dr.
Brothman has been involved in clinical and research cytogenetics since the late
‘70s. He has maintained clinical diagnostic
laboratories in Virginia and Utah which evaluate cells for chromosomal
abnormalities for both constitutional and acquired abnormalities. His primary research interests have been in
prostate cancer and technology applications.
Specifically, his group was among the first to study prostate tumors and
characterize chromosomal aberrations associated with the disease. This expanded to molecular analyses including
in-situ hybridization (FISH), comparative genomic hybridization (CGH), and most
recently CGH microarrays. He has translated all of these research technologies
into diagnostic testing through the clinical cytogenetics laboratory. His primary appointment at the University of Utah is in Pediatrics, and he holds
adjunct professorships in both Human Genetics and Pathology. Most recently, he has transitioned his
clinical cytogenetics laboratory and FISH laboratories to ARUP, and is
expanding his clinical molecular cytogenetics (formerly CGH microarray laboratory at the School of Medicine) laboratory also located at ARUP.
Dr. Brothman has been involved in teaching of undergraduates, graduates, residents and fellow in many aspects of genetics and cytogenetics. He served on (and was recently invited back to serve on) the College of American Pathologists/American College of Medical Genetics Cytogenetics Resource Committee where he has been charged with establishing a proficiency test for CGH microarrays. Included in his service work, he has been active in the SouthWest Oncology Group, the Children’s Oncology Group, multiple peer review committees through the National Institutes of Health and the American Cancer Society. He was elected to the Board of Directors for the American Cytogenetics Conference, and among other national appointments he is a Founding Fellow of the American College of Medical Genetics. He serves on the editorial board of the journal, Cancer Genetics and Cytogenetics, and is involved in multiple reviews of various journal articles and extramural grant applications each year. He has served on the University of Utah Academic Senate and was recently elected to the University of Utah Personnel and Elections Committee.
Selected Publications
- South ST, Whitby H, Maxwell T, Aston E, Brothman AR, Carey JC. (2008). Co-occurrence of 4p16.3 deletions with both paternal and maternal duplications of 11p15: modification of the Wolf-Hirschhorn syndrome phenotype by genetic alterations predicted to result in either a Beckwith-Wiedemann or Russell-Silver phenotype. Am J Med Genet A, 146A(20), 2691-7.
- Curry CJ, Mao R, Aston E, Mongia SK, Treisman T, Procter M, Chou B, Whitby H, South ST, Brothman AR. (2008). Homozygous deletions of a copy number change detected by array CGH: A new cause for mental retardation? Am J Med Genet A, 146A(15), 1903-1910.
- Saam J, Gudgeon J, Aston E, Brothman AR. (2008). How physicians use array comparative genomic hybridization results to guide patient management in children with developmental delay. Genet Med, 10(3), 181-6.
- South ST, Chen Z, Brothman AR. (2008). Genomic medicine in prenatal diagnosis. Clin Obstet Gynecol, 51(1), 62-73.
- Aston E, Whitby H, Maxwell T, Hair N, Cowley B, Lowry D, Zhu XL, Issa B, South ST, Brothman AR. (2008). Comparison of Targeted and Whole Genome Analysis of Postnatal Specimens Using a Commercially Available aCGH Microarray Platform. J Med Genet.
- South ST, Whitby H, Battaglia A, Carey JC, Brothman AR. (2008). Comprehensive analysis of Wolf-Hirschhorn syndrome using array CGH indicates a high prevalence of translocations. Eur J Hum Genet, 16(1), 45-52.
- Brothman, AR. (July 2008). 2008 Participant Summary Report. In ACMG/CAP CYCGH-A.
- South ST, Rope AF, Lamb AN, Aston E, Glaus N, Whitby H, Maxwell T, Zhu XL, Brothman AR. (2008). Expansion in size of a terminal deletion: a paradigm shift for parental follow-up studies [Letter to the editor]. J Med Genet, 45(6), 391-5.
- Rowe LR, Lee J, Rector LS, Kaminsky E, Brothman AR, Martin CL, South ST. (16 Mar 2009). U-type exchange is the most frequent mechanism for inverted duplication with terminal deletion rearrangements. J Med Genet, EPUB, ahead of Print.
- All Publications: Click Here
Honors and Awards
- 1995, Research Award – CaPCURE Foundation
Professional Education
- 1974 - 1978 B.S. University of Arizona (General Biology) Tucson, AZ
- 1978 - 1980 M.S. University of Arizona (Genetics) Tucson, AZ
- 1980 - 1982 Ph.D. University of Arizona (Genetics) Tucson, AZ
- 1982 - 1984 FELLOW Columbia University, College of Physicians and Surgeons (Human Genetics and Development) New York, NY
- 1984 - 1986 FELLOW Los Alamos National Laboratory (Experimental Pathology Group) Los Alamos, NM