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Arthur Brothman, Ph.D.
Professor Pediatrics
Adjunct Professor Human Genetics
Adjunct Professor Pathology
Arthur Brothman, Ph.D.
Titles:
- Director, Clinical Cytogenetics, University of Utah
- Director, CGH Microarray Laboratory, University of Utah
- Medical Director, Cytogenetics, ARUP
About Arthur Brothman, Ph.D.
Dr. Brothman has been involved in clinical and research cytogenetics since the late ‘70s. He has maintained clinical diagnostic laboratories in Virginia and Utah which evaluate cells for chromosomal abnormalities for both constitutional and acquired abnormalities. His primary research interests have been in prostate cancer and technology applications. Specifically, his group was among the first to study prostate tumors and characterize chromosomal aberrations associated with the disease. This expanded to molecular analyses including in-situ hybridization (FISH), comparative genomic hybridization (CGH), and most recently CGH microarrays. He has translated all of these research technologies into diagnostic testing through the clinical cytogenetics laboratory. His primary appointment at the University of Utah is in Pediatrics, and he holds adjunct professorships in both Human Genetics and Pathology. Most recently, he has transitioned his clinical cytogenetics laboratory and FISH laboratories to ARUP, and is expanding his clinical CGH microarray laboratory at the School of Medicine.
Dr. Brothman has been involved in teaching of undergraduates, graduates, residents and fellow in many aspects of genetics and cytogenetics. He served on (and was recently invited back to serve on) the College of American Pathologists/American College of Medical Genetics Cytogenetics Resource Committee where he has been charged with establishing a proficiency test for CGH microarrays. Included in his service work, he has been active in the SouthWest Oncology Group, the Children’s Oncology Group, multiple peer review committees through the National Institutes of Health and the American Cancer Society. He was elected to the Board of Directors for the American Cytogenetics Conference, and among other national appointments he is a Founding Fellow of the American College of Medical Genetics. He serves on the editorial board of the journal, Cancer Genetics and Cytogenetics, and is involved in multiple reviews of various journal articles and extramural grant applications each year. He has served on the University of Utah Academic Senate and was recently elected to the University of Utah Personnel and Elections Committee.
Selected Publications
- Svensson AM, Curry CJ, South ST, Whitby H, Maxwell TM, Aston E, Fisher J, Carmack CE, Scheffer A, Abu-Shamsieh A, Brothman AR. (2007). Detection of a de novo interstitial 2q microdeletion by CGH microarray analysis in a patient with limb malformations, microcephaly and mental retardation. Am J Med Genet A, 143(12), 1348-53.
- Lee C, Lafrate AJ, Brothman AR.. Copy number variation (CNV) and clinical cytogenetic diagnostics. Nat Genet 2007 Jul; 39 (7 Suppl): S48-54.
- Shaffer LG, Beaudet AL, Brothman AR, Hirsch B, Levy B, Martin CL, Mascarello JT, Rao KW. (2007). Microarray analysis for constitutional cytogenetic abnormalities. Genet Med, 9(9), 654-62.
- Bleyl SB, Byrne JLB, South ST, Dries DC, Stevenson DA, Rope AF, Vianna-Morgante AM, Schoenwolf GC, Kivlin JD, Brothman AR, Carey JC. Brachymesomelic Dysplasia with Peters Anomaly of the Eye Results from Disruptions of the X Chromosome near the SHOX and SOX3 Genes. Am J Med Genet A, 143(23), 2785-95 (2007).
- ST South, H Whitby, A. Battaglia, J.C. Carey, AR Brothman. Comprehensive analysis of Wolf-Hirschhorn syndrome using array CGH indicates a high prevalence of translocations. European Journal of Human Genetics, 16(1), 45-52, (2008).
- Aston E, Whitby H, Maxwell T, Hair N, Cowley B, Lowry D, Zhu XL, Issa B, South ST, Brothman AR. Comparison of Targeted and Whole Genome Analysis of Postnatal Specimens Using a Commercially Available aCGH Microarray Platform. J Med Genet. 2008 Jan 4 [EPub ahead of print] PMID: 18178633 [PubMed - as supplied by publisher]
- J. Saam, J Gudgeon, E Aston, A.R. Brothman. How physicians use array comparative genomic hybridization results to guide patient management in children with developmental delay. Genetics in Medicine 10(3):181-186, March 2008. PMID: 18344707 [PubMed - in process]
- South ST, Rope AF, Lamb AN, Aston E, Glaus N, Whitby H, Maxwell T, Zhu XL, Brothman AR. Expansion in size of a terminal deletion: A paradigm shift for parental follow-up studies. Journal of Medical Genetics (IN PRESS APR 2008).
- All Publications: Click Here
Honors and Awards
- 1995, Research Award – CaPCURE Foundation
Professional Education
- 1974 - 1978 B.S. University of Arizona (General Biology) Tucson, AZ
- 1978 - 1980 M.S. University of Arizona (Genetics) Tucson, AZ
- 1980 - 1982 Ph.D. University of Arizona (Genetics) Tucson, AZ
- 1982 - 1984 FELLOW Columbia University, College of Physicians and Surgeons (Human Genetics and Development) New York, NY
- 1984 - 1986 FELLOW Los Alamos National Laboratory (Experimental Pathology Group) Los Alamos, NM