Arthur Brothman, Ph.D.
Adjunct Professor Human Genetics
Adjunct Professor Pathology
Arthur Brothman, Ph.D.
- Medical Director, Cytogenetics & Genomic Microarray, ARUP Laboratories
About Arthur Brothman, Ph.D.
Dr. Brothman has been involved in clinical and research cytogenetics since the late ‘70s. He has maintained clinical diagnostic laboratories in Virginia and Utah which evaluate cells for chromosomal abnormalities for both constitutional and acquired abnormalities. His primary research interests have been in prostate cancer and technology applications. Specifically, his group was among the first to study prostate tumors and characterize chromosomal aberrations associated with the disease. This expanded to molecular analyses including in-situ hybridization (FISH), comparative genomic hybridization (CGH), and most recently CGH microarrays. He has translated all of these research technologies into diagnostic testing through the clinical cytogenetics laboratory. His primary appointment at the University of Utah is in Pediatrics, and he holds adjunct professorships in both Human Genetics and Pathology. Most recently, he has transitioned his clinical cytogenetics laboratory and FISH laboratories to ARUP, and is expanding his clinical molecular cytogenetics (formerly CGH microarray laboratory at the School of Medicine) laboratory also located at ARUP.
Dr. Brothman has been involved in teaching of undergraduates, graduates, residents and fellow in many aspects of genetics and cytogenetics. He served on the College of American Pathologists/American College of Medical Genetics Cytogenetics Resource Committee in proficiency testing of laboratories and designing checklists used for inspection for accrediation. Included in his service work, he has been active in the SouthWest Oncology Group, the Children’s Oncology Group, multiple peer review committees through the National Institutes of Health and the American Cancer Society . He is a former member of the Board of Directors for the American Cytogenetics Conference, and among other national appointments he is a Founding Fellow of the American College of Medical Genetics. He is Associate Editor of the journal, Cancer Genetics, and is involved in multiple reviews of various journal articles and extramural grant applications each year. He has served on the University of Utah Academic Senate and the University of Utah Personnel and Elections Committee.
- Lee C, Iafrate AJ, and Brothman AR. Copy number variation (CNV) and clinical cytogenetic diagnostics. Invited review, Nature Genetics, 39(7): S49-S54, (July 2007).
- Saam, J Gudgeon, E Aston, Brothman AR. How physicians use array comparative genomic hybridization results to guide patient management in children with developmental delay. Genetics in Medicine 10(3):181-186, March 2008.
- ST South, H Whitby, A. Battaglia, J.C. Carey, Brothman AR. Comprehensive analysis of Wolf-Hirschhorn syndrome using array CGH indicates a high prevalence of translocations. European Journal of Human Genetics, 16(1), 45-52, 2008.
- Aston E, Whitby H, Maxwell T, Hair N, Cowley B, Lowry D, Zhu XL, Issa B, South ST, Brothman AR Comparison of Targeted and Whole Genome Analysis of Postnatal Specimens Using a Commercially Available aCGH Microarray Platform. J Med Genet. 45:268-274,2008.
- South ST, Rope AF, Lamb AN, Aston E, Glaus N, Whitby H, Maxwell T, Zhu XL, Brothman AR. Expansion in size of a terminal deletion: A paradigm shift for parental follow-up studies. Journal of Medical Genetics 45(6):391-395,2008.
- Curry C, Mao R, Aston E, Mongia SK, Treisman T, Procter, M, Chou B, Whitby H, South ST, Brothman AR. Homozygous Deletions of a Copy Number Change detected by array CGH: A New Cause for Mental Retardation? Am J Med Genet A, 146A(15), 1903-1910, 2008.
- Whitby H, Tsalenko A, Aston E, Tsang P, Mitchell S, Bayrak-Toydemir P, Hopkins C, Peters G, Bailey, DK, Bruhn L, Brothman AR. Benign Copy Number Changes in Clinical Cytogenetic Diagnostics by Array CGH. Cytogenet Genome Res 123(1-4):94-101, 2008.
- Tsuchiya KD, Shaffer LG, Ardhya S, Biggerstaff J, Gastier-Foster J, Pater A, Rudd MK, Sanger W, Schwartz S, Tepperberg J, Thorland E, Torchia B, Brothman AR.. Variability in interpreting and reporting copy number changes detected by array-based technology in clinical laboratories. Genet Med., 11(12): 866-873, 2009.
- Warren, JE, Turok, DK, Maxwell TM, Silver RM, Brothman AR. Array Comparative Genomic Hybridization (aCGH) for Genetic Evaluation of Fetal Loss between 10 and 20 weeks Gestation. Obstetrics & Gynecology 114(5):1093-1102, 2009.
- Brothman AR, Persons DL, Shaffer LG. Nomenclature evolution: changes in the ISCN from the 2005 to the 2009 editions Cytogenet and Genome Res. 127:1-4,2009.
- Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Hamosh A, Jackson L, Kaminsky EB, Kok K, Krantz ID, Kuhn RM, Lee C,, Ostell JM, Rosenberg, C, Scherer SW, Spinner NB, Stavropoulos DJ, Tepperberg JH, Thorland E, Vermeesch JR,, Waggoner DJ, Watson MW, Martin CL, and Ledbetter DH. Consensus Statement on Cytogenomic Array as a First Tier Clinical Diagnostic Test for Children with Developmental Delay/Intellectual Disability, Autism Spectrum Disorders, and/or Multiple Congenital Anomalies. Am J Hum Genet, 86(5), 749-64, 2010.
- Yamada NA, Rector LS, Tsang P, Carr E, Scheffer A , Sederberg, MC, Aston ME, Ach RA, Tsalenko A, Sampas N, Peter B, Bruhn L, Brothman AR. Visualization of Fine-Scale Genomic Structure by Oligonucleotide-Based High Resolution FISH. Cytogenet Gen Res 132(4): 248-254, 2011.
- Gu G and Brothman AR. Cytogenomic aberrations associated with prostate cancer. Cancer Genetics 204:57-67, 2011.
- All Publications: Click Here
Honors and Awards
- 1995, Research Award – CaPCURE Foundation
- 1974 - 1978 B.S. University of Arizona (General Biology) Tucson, AZ
- 1978 - 1980 M.S. University of Arizona (Genetics) Tucson, AZ
- 1980 - 1982 Ph.D. University of Arizona (Genetics) Tucson, AZ
- 1982 - 1984 FELLOW Columbia University, College of Physicians and Surgeons (Human Genetics and Development) New York, NY
- 1984 - 1986 FELLOW Los Alamos National Laboratory (Experimental Pathology Group) Los Alamos, NM