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Todd Kelley, M.D.

last modified 2013-11-07 09:18 — by Mark Malcolm

Assistant Professor of Pathology

Scholarly Emphasis: The identification of novel prognostic biomarkers and therapeutic targets in leukemia and lymphoma.
Todd Kelley, M.D.

Todd Kelley, M.D.

Contact Info

Email Address: Todd.Kelley ~{at}~ path.utah.edu

Office Phone Number: 801-583-2787 X3559

Location: ARUP Laboratories

Research Lab: Todd Kelley's Lab

Also Works in: ARUP Institute for Clinical and Experimental Pathology  

Division: Clinical Pathology

Also Works in: ARUP  

Supporting Staff:   Mark Malcolm, M.S.   Leita Rogers  

 

About Todd Kelley, M.D.

 Dr Kelley is interested in identifying and evaluating new prognostic biomarkers in lymphoma and leukemia using flow cytometry, immunohistochemisty and proteomic techniques.   Since many of these biomarkers are inappropriately activated enzymes involved in cell signaling he is interested in evaluating their functional role in the signaling pathways that contribute to the development of a hematologic neoplasm.  The ultimate goal is to give the treating physician the ability to tailor therapy to the patient based on their individual risk.  Furthermore, new therapies may be designed which target these enzymes and pathways.  An additional interest is in the immunology of the lymphoma microenvironment.  Dr Kelley and colleagues have shown that a particular T cell signature in the Hodgkin lymphoma tumor microenvironment is predictive of clinical outcome.   Patients with tumors which contain higher numbers of regulatory T cells, as identified by expression of FOXP3, and lower numbers of activated cytotoxic T/NK cells based upon expression of granzyme B, have a significantly longer survival.  Based upon these findings, additional studies of the interactions between lymphoma cells and the immune infiltrate are ongoing.


Selected Publications

  • No Selected Publications Provided
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Professional Education

  • 2002 M.D.Ohio State University College of Medicine Columbus, Ohio USA
  • 1998 M.S. (Immunology and Microbiology)Ohio State University Columbus, Ohio USA
  • 1994 B.S. (Biological Sciences)Eckerd College St. Petersburg, Florida USA