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Harry Hill, M.D.

last modified 2013-01-09 11:13 — by Jeannette Hansen-Rejali

Professor of Pathology

Professor of Pediatrics

Professor of Internal Medicine (Adjunct)

Scholarly Emphasis: Dr. Hill’s research interest has been in understanding the humoral, cellular, cytokine, and molecular aspects of immunity to bacterial infections, particularly, group A and group B streptococci. He has also been involved in research in various immune def
Harry Hill, M.D.

Contact Info

Email Address: Harry.Hill {AT} path.utah.edu

Office Phone Number: (801) 581-5873

Location: 5B-114 SOM School of Medicine

Research Lab: ARUP Institute for Clinical and Experimental Pathology

Also Works in: Harry Hill's Lab  

Division: Clinical Pathology

Also Works in: ARUP  

Supporting Staff:   Jeannette Rejali  

 

Titles:

  • Head, Division of Clinical Pathology
  • Head, Clinical Immunology/Immunodeficiency Diseases
  • Associate Chair, Department of Pathology
  • Group Medial Director, Laboratories of Immunology and Infectious Diseases, ARUP Laboratories
  • Senior Vice President, ARUP Laboratories
  • Executive Director, ARUP Institute for Clinical and Experimental Pathology, (the research arm of ARUP Laboratories)

About Harry Hill, M.D.

Dr. Hill first came to the University of Utah in 1974 from the University of Minnesota as an Assistant Professor with an NIH grant directed at understanding the role of cyclic AMP and cyclic GMP in controling polymorphonuclear leukocyte and monocyte function in a variety of disease states associated with an unusual susceptibility to infection.  Subsequently, he turned his attention to host resistance against both group A and B streptococci, which are major causes of severe and overwhelming sepsis, pneumonia, septic shock syndrome, and necrotizing fasciitis.  He and his group first reported the absence of opsonic antibody to the various serotypes of group B streptococci as a major risk factor in early-onset group B streptococcal disease of the neonate.  Subsequently, he studied the role of whole blood transfusions and then intravenous immunoglobulin in the treatment of such infections in experimental animals and then in newborn infants in association with Dr. Robert Christensen.  He explored the functional activity of human monoclonal antibodies against the group B carbohydrate, which provided protection against the various serotypes of group B streptococci.  He pointed out the role of complement and, particularly, the C3dg component of complement in releasing marrow stores of neutrophils in group B disease.  He also was the first to describe the C5a-ase enzyme of group B streptococci (C5a-peptidase) which cleaves and inactivates the major chemotactic factor derived from complement – C5a.  Dr. Hill and his group then first pointed out the role of group B streptococci, a gram-positive organism, in releasing tumor necrosis factor contributing to the sepsis and shock that often accompanies infection due to these organisms. 

Dr. Hill’s lab was one of the first to demonstrate and describe the pathogenesis of abnormal neutrophil granulocyte movement in newborn infants and experimental animals.  He suggested that this was due to a deficiency in the production of interferon gamma, which could be corrected by recombinant interferon gamma and more recently the interferon gamma stimulating cytokines interleukin-12 and interleukin-18.  Neonatal mononuclear cells were shown to poorly transcribe mRNA for interferon gamma upon stimulation with group B organisms.  Working in the ARUP Institute for Clinical and Experimental Pathology, which Dr. Hill directs, he and his colleagues first developed a multi-analyte cytokine assay, which now can assess up to 14 different cytokines in 50-75 microliters of sample, which has allowed them to pursue the role of Th1 and Th2 lymphokines and monokines in promoting inflammatory and infectious disorders. 

Dr. Hill and Dr. George Veasy as well as other personnel at Primary Children’s Medical Center and the University of Utah have explored the large resurgence of acute rheumatic fever (ARF) that occurred throughout the Intermountain West surrounding Salt Lake City, which was published in the New England Journal of Medicine.  Recent follow-up studies on a long-term NIAID contract have documented the immune response to specific and nonspecific and cross-reactive streptococcal antigens, in ARF, using multianalyte technology.  A large number of samples from acute rheumatic fever cases, as well as, age-matched controls and uncomplicated pharyngitis patients, have been collected and are currently being analyzed for a variety of different humoral antibody, cytokine, and molecular abnormalities. 

More recently, working with Dr. Carl Wittwer and Dr. Karl Volkerding, Dr. Hill’s laboratory has began working on rapid molecular techniques for diagnosing immune deficiency diseases, especially chronic granulomatous disease and Job syndrome (Hyper IgE syndrome).

Selected Publications

  • Selected from over 200 peer-reviewed papers to illustrate major research activities since 1974.
  • Hill, H.R., Zimmerman, R.A., Reid, G.V.K., Wilson, E. and Kilton, R.M.: Food-borne epidemic of streptococcal pharyngitis at the United States Air Force Academy. New Engl. J. Med. 280:917-921, 1969.
  • Estensen, R.P., Hill, H.R., Quie, P.G., Hogan, N. and Goldberg, N.D.: Cyclic GMP and cell movement. Nature 245:458-460, Sept. 1973.
  • Hill, H.R., Gerrard, J., Hogan, N.A. and Quie, P.G.: Hyperactivity of neutrophil leukotactic responses during active bacterial infection. J. Clin. Invest. 53:996-1002, 1974.
  • Hill, H.R., Quie, P.G., Pabst, H.F., Ochs, H.D., Clark, R.A., Klebanoff, S.J., and Wedgwood, R.J.: Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses. Lancet ii:617-619, 1974.
  • Hemming, V.G., Hall, R.T., Rhodes, P.G., Shigeoka, A.O. and Hill, H.R.: Assessment of group B streptococcal opsonins in human and rabbit serum by neutrophil chemiluminescence. J. Clin. Invest. 48:1379-1387, 1976.
  • Hill, H.R., Shigeoka, A.O., Augustine, N.H., Pritchard, D., Egan, M.L., Lundblad, J.L. and Schwartz, R.S.: Fibronectin enhances the opsonic and protective activity of monoclonal and polyclonal antibody against group B streptococci. J. Exp. Med. 159:1618-1628, 1984.
  • Sacchi, F. and Hill, H.R.: Defective membrane potential changes in neutrophils from human neonates. J. Exp. Med. 160:1247-1252, 1984.
  • Veasy, L.G., Wiedmeier, S.E., Orsmond, G.S., Ruttenberg, H.D., Boucek, M.M., Roth, S.J., Tait, V.F., Thompson, J.A., Daly, J.A., Kaplan, E.L. and Hill, H.R.: Resurgence of acute rheumatic fever in the intermountain area of the United States. New Engl. J. Med. 316:421-427, 1987 (lead article).
  • Hill, H.R., Bohnsack, J.F., Morris, E.Z., Augustine, N.H., Parker, C.J., Cleary, P.P. and Wu, J.T.: Group B streptococci inhibit the chemotactic activity of the fifth component of complement. J. Immunol. 141:3551-3556, 1988.
  • Hill, H.R., Augustine, N.H., and Jaffe, H.S.: Human recombinant interferon gamma enhances neonatal PMN activation and movement and increases free intracellular calcium. J. Exp. Med. 173:767-770, 1991.
  • Shyur, S.D., Raff, H.V., Bohnsack, J.F., Kelsey, D.K., and Hill, H.R.: Comparison of the opsonic and complement triggering activity of human monoclonal IgG1 and IgM antibody against group B streptococci. J. Immunol. 148:1879-1884, 1992.
  • Martins, T.B., Pasi, B.M., Pickering, J.W., Jaskowski, T.D., Litwin, C.M., and Hill, H.R.: Determination of cytokine responses using a multiplex fluorescent microsphere immunoassay. Amer. J. Clin. Pathol. 118:346-353, 2002.
  • Martins, T.B., Anderson, J.L., Muhlestein, J.B., Horne, B.D., Carlquist, J.F., Roberts, W.L., and Hill, H.R.: Risk factor analysis of serum cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay. Amer. J. Clin. Path. 125:906-913, 2006.
  • All Publications: Click Here

Honors and Awards

  • Ross Award, Outstanding Investigator, Western Society for Pediatric Research, 1980
  • Investigator, Howard Hughes Medical Institute, 7/1/75-6/30/81
  • Diplomat American Board of Pediatrics (98 percentile)
  • Honor Roll Texas State Board of Medical Examiners
  • Alpha Epsilon Delta, Phi Eta Sigma
  • President, Lancefield Society, 1987-88
  • President, Western Society for Pediatric Research, 1993-94
  • Cited in The Best Doctors in America. Naifeh, S. and Smith, G.W.

Professional Education

  • 1960-1962 – pre-medical education - Louisiana State University, Baton Rouge, LA
  • 1966 – M.D. – (medicine) - Baylor Medical School, Houston, TX
  • 1966-1967 – Internship – Grady Memorial Hospital, Emory University, Atlanta GA
  • 1967-1969 - Epidemic Intelligence Service Officer, (Center for Disease Control). Assigned to the Streptococcal and Arboviral Diseases Section of the Ecological Investigation Program, Fort Collins, CO
  • 1969-1971 – Pediatrics Residency and Post-Doctoral Fellow in Immunology, University of Washington, Seattle, WA
  • 1971-1974 – Fellow – Infectious Diseases/Host Resistance/Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN